Drug Design for Neuropathic Pain Regulation from Traditional Chinese Medicine
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چکیده
منابع مشابه
Drug Design for Neuropathic Pain Regulation from Traditional Chinese Medicine
FAAH-like anandamide transporter (FLAT) regulates anandamide transport for hydrolysis and may be an attractive drug target for pain regulation. We aimed to discover potential FLAT antagonists from traditional Chinese medicine (TCM) using virtual screening, ligand-based drug design and molecular dynamics simulation (MD). Guineensine and Retrofractamide A exhibited high Dock Scores in FLAT. Conse...
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Computer-aided drug design (CADD) is an interdisciplinary subject, playing a pivotal role during new drug research and development, especially the discovery and optimization of lead compounds. Traditional Chinese Medicine (TCM) modernization is the only way of TCM development and also an effective approach to the development of new drugs and the discovery of potential drug targets (PDTs). Disco...
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One has found an important cell cycle controller. This guard can decide the cell cycle toward proliferation or quiescence. Cyclin-dependent kinase 2 (CDK2) is a unique target among the CDK family in melanoma therapy. We attempted to find out TCM compounds from TCM Database@Taiwan that have the ability to inhibit the activity of CDK2 by systems biology. We selected Tetrahydropalmatine, Reserpili...
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1938 www.thelancet.com Vol 372 December 6, 2008 transplantations. At present, 87 institutions have full approval from the Ministry of Health; 77 others have provisional approval and 18 months to comply with all the regulations. This number is a reduction from the more than 600 institutions that did transplants 1 year ago. Regulations have been set up to ban transplant tourism. The penalty for p...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2013
ISSN: 2045-2322
DOI: 10.1038/srep00844